Louie Louie in the movies

Say It Isn't So
Director James B. Rogers
Year 2001
Cast Chris Klein, Heather Graham, Sally Field
Louie Louie performed by The Kingsmen
A young man (Klein) finds out his lover (Graham) may actually be his biological sister. After they break up he discovers he's not related and travels across the country to stop her impending wedding. Unfortunately the entire nation has heard the same story and thinks he's just after incestuous thrills.